It's a beta - and I have looked at the skins using Google Chrome on http://xdmediablue.dnnskins.com/home.aspx and it appears ok, but if you've modified the CSS then you may need to look at the code a little more to make it more compliant.
By the way - it's using a very old webkit engine from safari 3.0 days and could have several vulnerabilities.
And the editor doesn't work in it either...
I think we need to see a more stable release come out before people start modifying their designs to suit.
Sorry I can't help yet - but if it's an issue when the Chrome is out of beta then it might be worth looking at.